Nuclear metabolism for the win! We are excited to publish two back-to-back manuscripts about nuclear metabolism. While the stories diverge into distinct concepts, it's exciting to see metabolic enzymes do so much in the nucleus. Read the original publication about MTHFD2 at Nature Communications.Nuclear localization of...
In an exciting new strategy, Savvas hypothetized that antibody enrichment would enrich modified (PTMs) and mutated bait peptides. Using MSFragger Open Search (Nesvilab) coupled to SAINTexpress, we identify differentially present peptidoforms.By re-analyzing the publicly available #HRAS WT vs. G12D interactomes, we specifically identify the positive...
Our lab at the Centre for Genomic Regulation together with collaborators from the Vall d’Hebron Institute of Oncology has made an important discovery that could lead to new treatments for triple-negative breast cancer. This aggressive form of breast cancer lacks the receptors targeted by current...
A new study co-led by Savvas Kourtis from our lab and Amandine Moretton from Joanna Loizou's lab at the CeMM, Vienna reveals that in response to DNA damage, such as from chemotherapy drugs, the nucleus of a cell activates antioxidant enzymes to protect itself. We...
Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states...
