We recently described that enzymes of central metabolism can localize on chromatin in cancer cells. The central role of metabolic rewiring during cancer progression is undeniable, but its direct impact on chromatin functions has been poorly investigated. The scope of our research is to dissect the role of enzymatic activities on chromatin, with a particular focus on cancer.
Our research focuses on a brand-new area of cancer biology and has the potential to uncover novel chromatin-associated metabolic vulnerabilities.
Genetic screens allow us to identify functional partners of chromatin associated metabolic enzymes.
Chemical screens allow us to scout for compounds inhibiting chromatin-associated functions of metabolic enzymes.
Cell cycle tracking allows us to determine the role of important enzymes in regulating cell proliferation.
Exploring proteoforms allows us to discover and evaluate novel roles of enzyme encoded by the same genotype space.