Savvas Kourtis from our lab recently visited the lab of Kathryn Lilley, whose research focuses on developing and applying high-throughput technologies to measure the dynamic proteome and transcriptome in cells over time and space.
Specifically, Dr. Lilley’s group looks at changes in protein abundance, localization, interactions, PTMs, and structure during cellular processes like differentiation. They also examine the subcellular distribution of the transcriptome upon perturbation, the proteins that form ribonuclear complexes, and the spatial and temporal links between protein trafficking and the corresponding transcriptome. This involves experimental pipelines using mass spectrometry, RNA-seq, and computational tools to dissect mechanisms related to stress, drug treatment, differentiation, and disease in collaborative projects.
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